Abcam, ab138210, Anti-ZDHHC7 antibody

Size: 100µg
Rabbit Polyclonal ZDHHC7 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human Palmitoyltransferase ZDHHC7.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Palmitoyltransferase ZDHHC7. The exact immunogen used to generate this antibody is proprietary information.Q9NXF8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab138210 was affinity-purified from rabbit antiserum by immunogenic peptide affinity-chromatography., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZDHHC7 also known as Zinc Finger DHHC-Type Palmitoyltransferase 7 is an enzyme with a molecular mass of approximately 66 kDa. This protein plays an important role in the palmitoylation process which involves attaching palmitic acid to cysteine residues of target proteins. ZDHHC7 is widely expressed in various tissues including neurons liver and heart highlighting its importance in different physiological processes. This protein acts by facilitating the transfer of palmitate to substrates which can influence their localization and stability within cells.
Biological function summary
Zinc Finger DHHC-Type Palmitoyltransferase 7 influences cell signaling and membrane trafficking. It is part of a multi-protein complex that ensures the accurate delivery of proteins to cellular membranes where they perform specific functions. ZDHHC7 modifies signaling molecules impacting pathways related to growth and development. The lipid modification of proteins by ZDHHC7 can also affect cellular communication contributing to the regulation of signal transduction and vesicular transport across different cell types.
Pathways
ZDHHC7 participates in the palmitoylation pathway which is essential for the membrane association and function of many signaling proteins. The Hedgehog signaling pathway is one significant pathway where ZDHHC7 exerts its influence modulating the activity of proteins like Shh. ZDHHC7-related palmitoylation affects the Ras family of GTPases which are vital players in cell proliferation and differentiation. This activity fosters dynamic changes in the cell membrane composition aligning with various cellular reactiveness in response to environmental cues.
Abnormalities in ZDHHC7 function have been linked to Huntington's disease and cancer. Disruptions in its palmitoylation activity can lead to the mislocalization and dysfunction of proteins that are critical for neural stability and cell cycle regulation. In Huntington's disease ZDHHC7 interacts with mutant huntingtin protein which alters its normal palmitoylation pattern. In cancer abnormal ZDHHC7 expression affects proteins like oncogenic Ras enhancing oncogenesis. Understanding these interactions offers avenues for potential therapeutic strategies targeting the aberrant activity of these proteins in diseases.