Abcam, ab138425, Anti-LIN54 antibody

Size: 100µg
Rabbit Polyclonal LIN54 antibody. Suitable for IP and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human LIN54 aa 50-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human LIN54 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.Q6MZP7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99.01% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LIN54 also known as protein LINT-54 is a component of the DREAM complex involved in cell cycle regulation. This protein has a molecular weight of around 70 kDa and is expressed in various tissues throughout the body including the brain and lungs. LIN54 contains specific DNA-binding domains that enable it to interact directly with DNA allowing it to regulate the transcription of target genes. By binding to specific DNA sequences this protein helps control key biological processes necessary for cell proliferation.
Biological function summary
In coordination with other proteins LIN54 plays an important role in the regulation of the cell cycle. It forms part of the multiprotein DREAM complex a regulatory unit that shifts cells from proliferation to a quiescent state by repressing cell cycle-dependent genes. During the cell cycle LIN54 supports transitions between different phases by regulating gene expression connected to cell cycle arrest and activation ensuring cells divide correctly and avoid errors that could lead to pathological states.
Pathways
Multiple cell cycle pathways involve the participation of LIN54 influencing cellular transitions and growth signals. LIN54 is significantly associated with the E2F transcription factor pathway which regulates genes required for cell cycle progression. Another pathway that LIN54 plays a part in is the p53 signaling pathway where it interacts with proteins like RB1. These pathways help maintain cellular homeostasis and prevent unregulated growth that may result in various diseases.
LIN54 shows connections to cancer and neurodegenerative diseases. Aberrant expression or regulation of LIN54 could lead to uncontrollable cell proliferation seen in cancers. One of its associations in cancer involves the interaction with RB1 commonly mutated in various cancers. Additionally dysregulation in the DREAM complex including LIN54 might relate to neurodegenerative diseases like Alzheimer's where cell cycle control in neurons is disrupted. Understanding LIN54's role in these diseases could help develop therapeutic strategies targeting these pathways.