Abcam, ab139689, Anti-NSMCE1 antibody [EPR9103(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NSMCE1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9103(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The NSMCE1 protein also known as non-SMC element 1 homolog is an essential component of the SMC5-SMC6 complex. It has a molecular mass of approximately 25 kDa and plays a pivotal mechanical role in DNA repair and replication processes. NSMCE1 expresses in various tissues showing higher levels in proliferative cells due to its need in maintaining genomic stability. This protein interacts with other structural maintenance of chromosome (SMC) proteins to facilitate these vital cellular functions.
Biological function summary
DNA repair and replication depend on NSMCE1 as it participates in the SMC5-SMC6 complex. This complex functions effectively in regulating chromosome segregation and maintaining genomic integrity during the cell cycle. Without NSMCE1 cells exhibit impaired repair of DNA double-strand breaks and defects in the homologous recombination pathway leading to genomic instability. The complex itself requires NSMCE1 to ensure accurate cell division and prevent harmful mutations.
Pathways
NSMCE1 engages heavily in the DNA damage response and homologous recombination pathways. Its interaction is important with the SMC5-SMC6 complex which collaborates with proteins like RAD51 and BRCA1 during DNA repair mechanisms. These pathways play an important role in the repair of DNA breaks safeguarding the genome against potential damage. NSMCE1 through these interactions helps preserve genetic integrity by ensuring the proper repair and replication of DNA under stress conditions.
Defects in NSMCE1 expression associates with cancer and genomic instability disorders. Its impairment could disrupt the function of the SMC5-SMC6 complex leading to increased susceptibility to cancers due to flawed DNA repair mechanisms. NSMCE1 shows links to BRCA1-related breast cancer due to its role in the homologous recombination pathway. By understanding NSMCE1's involvement in these diseases research moves closer to developing targeted therapies for conditions stemming from its dysfunction.