Abcam, ab140131, Anti-Calcipressin 1/RCAN1 antibody [EPR8911]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Calcipressin 1/RCAN1 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8911,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Calcipressin 1 also known as RCAN1 is a protein that plays a central role in regulating calcineurin activity. This protein weighs around 29-31 kDa. It is found in various human tissues especially in the heart brain and skeletal muscle. By binding to calcineurin RCAN1 inhibits its phosphatase activity influencing cellular pathways that rely on calcium signaling.
Biological function summary
Within the cell RCAN1 functions as a modulator of calcineurin-dependent transcriptional activity. It interacts with several proteins including those in the signaling complex linked to the NFAT (nuclear factor of activated T-cells). By managing the activity of calcineurin RCAN1 influences the transcription of genes involved in growth development and immune responses. Therefore its role is critical in maintaining cellular homeostasis and response to changes in calcium levels.
Pathways
RCAN1 impacts the calcineurin-NFAT signaling and MAPK (mitogen-activated protein kinase) pathways. In the calcineurin-NFAT pathway RCAN1 influences T-cell activation and the immune response by modulating NFAT's transcriptional activity. Moreover the MAPK pathway which is important for cell proliferation and differentiation sees regulation through RCAN1's action on calcineurin interfacing with kinases like JNK (c-Jun N-terminal kinase) to adjust signaling outputs.
Alterations in RCAN1 expression or function associate with Down syndrome and Alzheimer's disease. Increased RCAN1 levels often seen in Down syndrome lead to reduced calcineurin function affecting neuronal signaling pathways. In Alzheimer's disease the interaction with proteins like Tau contributes to neurodegenerative processes. Understanding RCAN1's involvement provides insights into potential therapeutic targets for these conditions.