Abcam, ab140440, Anti-Proteasome 26S S3/PSMD3 antibody

Size: 100µg
Rabbit Polyclonal Proteasome 26S S3/PSMD3 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PSMD3 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PSMD3 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.O43242

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab140440 was affinity purified using an epitope specific to Proteasome 26S S3/PSMD3 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Proteasome 26S S3 also known as PSMD3 is an essential component of the 26S proteasome complex which plays a critical role in degrading ubiquitinated proteins. It has a molecular mass of approximately 61 kDa and is important in maintaining protein homeostasis by regulating protein degradation. The 26S proteasome is expressed ubiquitously in eukaryotic cells indicating its importance in various cellular processes. Its activity ensures the removal of damaged or misfolded proteins which is necessary for proper cellular function and survival.
Biological function summary
Proteasome 26S S3 forms an integral part of the 26S proteasome a large complex involved in the ATP-dependent breakdown of proteins. This complex is essential for many cellular functions including cell cycle progression signal transduction and stress responses. By facilitating protein degradation Proteasome 26S S3 helps regulate the quantity and quality of proteins within the cell. It interacts with other proteasomal components to mediate the recognition and unfolding of target proteins enabling their subsequent degradation into smaller peptides.
Pathways
The Proteasome 26S S3 participates in the ubiquitin-proteasome pathway and the NF-κB signaling pathway. These pathways are pivotal in controlling protein turnover and are involved in cellular responses to various stimuli. Within the ubiquitin-proteasome pathway PSMD3 collaborates with other proteasome components to execute protein degradation processes. In the NF-κB pathway PSMD3 influences the degradation of IκB proteins allowing the activation of NF-κB transcription factors which regulate immune and inflammatory responses.
Dysregulation of Proteasome 26S S3 activity has links to cancer and neurodegenerative diseases. Abnormal proteasome function can result in the accumulation of damaged proteins contributing to the pathogenesis of these conditions. In cancer alterations in the proteasome function can lead to uncontrolled cell growth and survival where PSMD3 interacts with proteins like p53 and Bcl-2 affecting apoptosis and cell cycle regulation. In neurodegenerative diseases compromised proteasome activity may lead to the accumulation of misfolded proteins exacerbating conditions such as Alzheimer's or Parkinson's disease.