Abcam, ab140619, Anti-CAMSAP2 antibody [EPR7718(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CAMSAP2 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7718(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CAMSAP2 also known as calmodulin-regulated spectrin-associated protein family member 2 is a microtubule-stabilizing protein with a molecular mass of approximately 198 kDa. It binds to the minus ends of microtubules stabilizing them and regulating their dynamics. CAMSAP2 is expressed in various tissues with a significant presence in neuronal tissue. The protein plays a vital role in stabilizing the microtubule network which influences cellular architecture and intracellular transport.
Biological function summary
The regulation of microtubule dynamics by CAMSAP2 ensures proper neuronal development and function. CAMSAP2 is part of a protein complex that is essential for maintaining microtubule integrity and organization. It interacts with other proteins such as CAMSAP1 and CAMSAP3 each playing distinct roles in microtubule arrangement. These interactions help in maintaining cellular structures which are necessary for processes like cellular division and differentiation.
Pathways
CAMSAP2 is involved in microtubule-associated pathways critical for cell stability and signaling. The protein is part of the axon guidance pathway where it functions alongside other proteins including PTEN and CRMP2 to ensure correct neural network formation. CAMSAP2 also engages in the regulation of cytoskeleton organization pathways where it collaborates with microtubule-associated proteins to support cellular morphology and dynamics.
CAMSAP2 plays a part in conditions affecting the nervous system such as neurodevelopmental disorders and certain neurodegenerative diseases. Mutations or dysregulation of CAMSAP2 have been linked to intellectual disabilities due to its role in neuronal structure and signaling. This protein also interacts with tau a protein commonly associated with neurodegenerative disorders like Alzheimer's disease suggesting a potential link between CAMSAP2 function and tauopathies.