Abcam, ab140795, Anti-GPR91 antibody - Cytoplasmic domain

Size: 50µg
Rabbit Polyclonal GPR91 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human SUCNR1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SUCNR1. The exact immunogen used to generate this antibody is proprietary information.Q9BXA5,
Specificity:BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPR91 also known as succinate receptor 1 is a G-protein-coupled receptor with a mass of approximately 32 kDa. It localizes to the cell membrane and is most prominently expressed in the kidneys liver and retinal tissue. The receptor consists of seven transmembrane domains with both cytoplasmic domain and cytoplasmic region playing important roles in signal transduction. It senses extracellular succinate levels and helps to mediate various cellular responses.
Biological function summary
GPR91 acts as a sensor for succinate an intermediate of the tricarboxylic acid cycle. When succinate binds to GPR91 it initiates a signaling cascade involving the activation of downstream effectors such as intracellular Ca2+ and ERK1/2. This receptor is not a part of a large receptor complex instead it interacts directly with kinases and other signaling molecules. The response can induce angiogenesis especially under conditions of ocular stress and hypoxia indicating its role in retaining physiological balance.
Pathways
GPR91 is significantly involved in the metabolic and inflammatory pathways. In metabolic pathways it works closely with proteins like HIF-1α conveying changes in cellular energy status. The receptor also intersects with inflammatory pathways by modulating immune responses through production of reactive oxygen species and cytokines. Both pathways highlight important roles of GPR91 in cellular adaptation to metabolic and environmental cues.
GPR91 shows associations with diabetic retinopathy and ischemic kidney disease. In diabetic retinopathy GPR91 activation can lead to inappropriate angiogenesis making it a contributor to disease progression. Similarly in ischemic kidney disease the receptor's involvement in hypoxic signaling can exacerbate kidney damage by interacting with related receptors like GPR99 in the renal system. These insights suggest potential therapeutic targets within GPR91 signaling for these conditions.