Abcam, ab140831, Anti-SLC7A2/CAT2 antibody

Size: 50µg
Rabbit Polyclonal SLC7A2/CAT2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SLC7A2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC7A2. The exact immunogen used to generate this antibody is proprietary information.P52569,
Specificity:BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TPR (67%).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLC7A2 commonly known as CAT2 functions as a cationic amino acid transporter. This protein weighs around 72 kDa and is essential for the uptake of cationic amino acids such as arginine lysine and ornithine. Expression of SLC7A2 happens in various tissues including liver kidney and skeletal muscle. It is a member of the larger solute carrier family specifically the SLC7 family which plays roles in transporting nutrients across the cell membrane.
Biological function summary
SLC7A2 contributes to the regulation of nitric oxide production by modulating the intracellular availability of arginine an important substrate for nitric oxide synthase. The protein does not appear to work as a part of a well-characterized complex but its independent activity can significantly influence cellular functions. By impacting arginine transport SLC7A2 affects various cellular processes like immune response and vascular function.
Pathways
SLC7A2 serves a role in the nitric oxide synthesis pathway and the urea cycle. It interacts indirectly with proteins such as nitric oxide synthase which requires arginine supplied by SLC7A2 for nitric oxide production. SLC7A2 influences pathways like vasodilation and immune signaling by controlling the movement and availability of its substrate amino acids.
Misregulation or mutation of SLC7A2 links to hypertensive disorders and certain metabolic syndromes. The protein's role in arginine transport connects to situations such as endothelial dysfunction where reduced nitric oxide levels lead to cardiovascular issues. Researchers study its relationship with nitric oxide synthase further to understand the mechanistic basis of these health conditions.