Abcam, ab141003, MG-132, proteasome inhibitor

Size: 5mg / 25mg
MG-132 (ab141003) is a proteasome inhibitor and contains the nodifications: N-terminal benzyloxycarbonyl; C-terminal aldehyde.  Molecular weight (MW) 475.6, Purity >98%. - Proven performance: cited in over 50 publications - Available in different sizes to fit your experimental needs
Key facts
CAS number:133407-82-6,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:475.6 Da,
Molecular formula:C26H41N3O5,
PubChem:462382,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM but unstable for prolonged periods.Soluble in ethanol to 100 mM.,
Biochemical name:Z-Leu-leu-leu-al,
Biological description:LLL (Modifications: N-terminal benzyloxycarbonyl; C-terminal aldehyde),
Canonical smiles:CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1,
Isomeric smiles:CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1,
InChi:InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1,
InChiKey:TZYWCYJVHRLUCT-VABKMULXSA-N,
IUPAC Name:benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-It is important to note that this is air sensitive and impurities can occur as a result of air oxidation|Store under desiccating conditions

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Proteasome subunit beta type 2 or PSMB2 also known as PSMB5/MB1 is an essential component of the proteasome complex with a molecular weight of approximately 26 kDa. This subunit participates in the assembly of the 20S core protease complex important for protein degradation functions within cells. PSMB2 is ubiquitously expressed in various tissues reflecting its broad role in cellular homeostasis. It contributes to the active sites of the proteasome facilitating the breakdown of ubiquitinated proteins.
Biological function summary
The PSMB2 and PSMB5 subunits play a role in regulated protein degradation as part of the ATP-dependent 26S proteasome complex. This complex orchestrates the degradation of unneeded or damaged proteins by proteolysis a chemical reaction that breaks peptide bonds. PSMB2 aids in maintaining protein quality control and cellular regulation by processing peptides into smaller fragments for further degradation or presentation by MHC class I molecules. Its activity is essential for regulating numerous cellular processes including cell cycle control signal transduction and immune responses.
Pathways
The PSMB2 protein participates in key pathways such as the ubiquitin-proteasome pathway and the NF-κB signaling pathway. Its involvement in these pathways highlights its role in protein homeostasis and immune regulation within cells. The ubiquitin-proteasome pathway relies on several other proteins including ubiquitin itself and E3 ligases which tag proteins for degradation. PSMB2 collaborates with similar subunits to execute regulated protein breakdown ensuring proper cell function and adaptive responses to cellular stress.
PSMB2's dysregulation associates with conditions such as multiple myeloma and certain neurodegenerative disorders like Alzheimer's disease. In multiple myeloma alterations in PSMB2 expression contribute to the enhanced survival of malignant cells which may involve interactions with other proteasome inhibitors like MG132. This connection highlights potential therapeutic avenues targeting proteasome components to ameliorate disease symptoms and progression. In Alzheimer's disease PSMB2 may intertwine with amyloid precursor protein processing influencing pathogenic protein aggregation and neuronal damage.