Abcam, ab141043, Tropicamide, M4 antagonist

Size: 100mg
MW 284.35 Da, Purity >98%. Potent, selective M4 antagonist (pKi = 7.85). Achieve your results faster with highly validated, pure and trusted compounds.
Key facts
CAS number:1508-75-4,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:284.35 Da,
Molecular formula:C17H20N2O2,
PubChem:5593,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mMSoluble in ethanol to 20 mM,
Biochemical name:Tropicamide,
Biological description:Potent, selective M4 antagonist (pKi = 7.85).,
Canonical smiles:CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2,
InChi:InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3,
InChiKey:BGDKAVGWHJFAGW-UHFFFAOYSA-N,
IUPAC Name:N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Muscarinic acetylcholine receptors specifically CHRM1 CHRM3 CHRM4 and CHRM5 are part of the G protein-coupled receptor family. These receptors also known by names such as M1-M5 receptors play critical roles in mediating cholinergic neurotransmission. Molecular weights vary among these receptors but they generally range around 70 kDa. These receptors are highly expressed in central nervous system regions such as cerebral cortex hippocampus and striatum as well as some peripheral tissues. Aromatase another biological target functions as an enzyme that converts androgens to estrogens and is expressed in various tissues including the brain and gonads.
Biological function summary
Muscarinic receptors affect numerous processes by regulating neurotransmitter release and they are integral to modulating synaptic plasticity memory and learning. They do not form part of a complex but interact with various signaling molecules. Aromatase's biological role involves steroid hormone conversion important for maintaining hormonal balances. Its activity leads to estrogen production impacting reproductive and non-reproductive tissues importantly in the maintenance of physiological homeostasis.
Pathways
These receptors participate prominently in cholinergic pathways that influence cognitive and autonomic functions. They interact with signaling proteins like G-proteins and second messengers which mediate neurotransmission and physiological responses. Aromatase fits primarily into steroidogenesis pathways working alongside steroidogenic enzymes to modulate hormone profiles and impact various metabolic and cellular activities.
Muscarinic receptors are implicated in neurological conditions such as Alzheimer’s disease and schizophrenia. Deregulation of these receptors connects to imbalances in neurotransmission and cognitive functions. Aromatase is associated with hormone-dependent cancers like breast cancer given its role in estrogen production. Its activity links to estrogen receptors highlighting its influence on estrogen-responsive tissues in cancer progression and therapy outcomes.