Abcam, ab14106, Anti-TAGLN/Transgelin antibody

Size: 100µg
Anti-TAGLN/Transgelin antibody (ab14106) is a rabbit polyclonal antibody detecting TAGLN/Transgelin in Western Blot, ICC/IF . Suitable for Human, Mouse, Rat . - Over 430 publications - Trusted since 2005
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:The immunogen used to generate this TAGLN/Transgelin antibody (ab14106) shares 75% homology with family members TAGLN2 and TAGLN3. Cross-reactivity with these proteins has not been confirmed experimentally.

Product details:
Product Specifications
Anti-TAGLN/Transgelin antibody (ab14106) is a rabbit polyclonal antibody and is validated for use in ICC/IF, WB in human, mouse, rat samples.
Quality and Validation
Anti-TAGLN/Transgelin antibody (ab14106) specifically detects TAGLN/Transgelin (UniProt ID: Q01995; Molecular weight: 22kDa) and is sold in 100 µg selling sizes.
Abcam's high quality validation processes ensure Anti-TAGLN/Transgelin antibody (ab14106) has high sensitivity and specificity.
Anti-TAGLN/Transgelin antibody (ab14106) has been cited over 435 times in peer reviewed journals and is trusted by the scientific community.
Anti-TAGLN/Transgelin antibody (ab14106) has 27 independent reviews from customers.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TAGLN also known as Transgelin or SM22-alpha is a protein with a molecular weight of approximately 22 kDa. Structurally it belongs to the calponin family and contains an ACT domain which is critical for its actin-binding ability. It is expressed abundantly in smooth muscle cells where it stabilizes cytoskeletal dynamics by interacting with actin filaments. TAGLN also shows expression in fibroblasts and myofibroblasts supporting structural integrity and cellular movement.
Biological function summary
The regulatory involvement of TAGLN in smooth muscle contraction influences cellular activities essential for vascular function. This protein modulates remodeling and differentiation within smooth muscle cells. It can associate with actin and calponin to form complexes that regulate the stability of cytoskeletal structures ensuring effective cellular responses to mechanical stimuli. By linking signal transduction to cytoskeletal mechanics TAGLN facilitates the maintenance of cell shape and tension.
Pathways
TAGLN plays a role in the regulation of the RhoA/Rho kinase pathway contributing to actin cytoskeleton organization and smooth muscle contraction. Additionally it is involved in the WNT signaling pathway influencing cell proliferation and differentiation. In these pathways TAGLN works with proteins like RhoA and beta-catenin to transmit signals from the extracellular environment to the nucleus impacting gene expression and cellular responses.
Disruptions in TAGLN expression associate with vascular diseases and certain cancers. Downregulation or altered expression patterns can lead to smooth muscle cell dysfunction contributing to atherosclerosis. Similarly TAGLN interacts with proteins such as fibronectin and MMP2 in cancer where its altered expression could promote metastasis and tumor progression. Understanding these connections highlights TAGLN's potential as a target for therapeutic interventions in these diseases.