Abcam, ab141066, Oleanolic acid, Natural triterpenoid

Size: 100mg / 500mg
MW 456.7 Da, Purity >96%. Natural triterpenoid. Various pharmacological attributes. Antiviral, anti-inflammatory, antiangiogenic, antiapoptotic and antitumor activities in vitro and in vivo .
Key facts
CAS number:508-02-1,
Purity:>96%,
Form:SolidSee storage information,
Source:Olea Europaea,
Molecular weight:456.7 Da,
Molecular formula:C30H48O3,
PubChem:10494,
Nature:Native,
Solubility:Soluble in DMSO to 10 mMSoluble in ethanol to 10 mM,
Biochemical name:Oleanolic acid,
Biological description:Natural triterpenoid. Various pharmacological attributes. Antiviral, anti-inflammatory, antiangiogenic, antiapoptotic and antitumor activities in vitro and in vivo.,
Canonical smiles:CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1)C)C(=O)O)C,
Isomeric smiles:C[C@]12CC[C@@H](C([C@@H]1CC[C@@]3([C@@H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O)C)C)(C)C)O,
InChi:InChI=1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,23-,27-,28+,29+,30-/m0/s1,
InChiKey:MIJYXULNPSFWEK-GTOFXWBISA-N,
IUPAC Name:(4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CD45RO also known as PTPRC functions as a protein tyrosine phosphatase involved in lymphocyte signaling. This protein exists on the surface of mature T-cells and memory T-cells and has a molecular mass of approximately 200 kDa. CD45RO influences T-cell receptor signaling through dephosphorylation of specific substrates affecting the immune response. It is expressed mostly in hematopoietic cells. Additionally other targets like NF-kB p65 and DNA Polymerase beta interact with cell signaling and DNA repair processes respectively and have distinct expression and functions in different cell types. Targets like acid phosphatase (ACP1) have broader enzymatic roles impacting cellular metabolism and growth.
Biological function summary
Proteins such as CD45RO play roles in signal transduction within immune cells. This phosphatase does not function alone; it is part of larger complexes that regulate immune responses. Targets like NF-kB p65 form transcription complexes that manage inflammation and cell survival. Furthermore Acid phosphatase/ACP1 facilitates cellular phosphate metabolism supporting various cellular processes. DNA Polymerase beta functions importantly in the base excision repair complex addressing DNA damage efficiently. These targets act synergistically with natural immunomodulators to maintain cellular and systemic homeostasis.
Pathways
Proteins like CD45RO and GPCR TGR5 participate in the immune and metabolic signaling pathways. CD45RO influences pathways involving kinases such as Lck and Fyn which are critical to T-cell receptor mediated signal transduction. In parallel GPCR TGR5 modulates metabolic pathways influencing energy expenditure and bile acid signaling. The nuclear factor NF-kB p65 is a significant player in pathways controlling immune and inflammatory responses interacting with ather at a molecular level. Proper regulation of these pathways ensures balanced cellular physiology and immune responses.
Proteins such as CD45RO and NF-kB p65 have implications in conditions like autoimmune disorders and cancer. Aberrant CD45RO expression or function associates with autoimmune diseases such as rheumatoid arthritis where it interacts abnormally with other phosphatases like SHP1 and SHP2. Meanwhile NF-kB p65's dysregulation relates to cancer development as it affects the transcriptional response to inflammatory signals involving partners like DNA Polymerase beta. These connections highlight the importance of these targets in disease mechanisms and potential therapeutic strategies.