Abcam, ab141134, Nisoxetine hydrochloride, norepinephrine reuptake (NET) inhibitor

Size: 10mg / 50mg
MW 307.8 Da, Purity >99%. Potent and selective norepinephrine reuptake (NET) inhibitor (K i values are 0.46, 158 and 505 nM for NET, SERT and DAT, respectively).
Key facts
CAS number:57754-86-6,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:307.8 Da,
Molecular formula:C17H22ClNO2,
PubChem:134453,
Nature:Synthetic,
Solubility:Soluble in water to 100 mM,
Biochemical name:Nisoxetine hydrochloride,
Biological description:Potent and selective norepinephrine reuptake (NET) inhibitor (Ki values are 0.46, 158 and 505 nM for NET, SERT and DAT, respectively).,
Canonical smiles:CNCCC(C1=CC=CC=C1)OC2=CC=CC=C2OC.Cl,
InChi:InChI=1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H,
InChiKey:LCEURBZEQJZUPV-UHFFFAOYSA-N,
IUPAC Name:3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine;hydrochloride

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TDP1 also known as tyrosyl-DNA phosphodiesterase 1 is an important protein involved in DNA repair. It weighs around 66 kDa. TDP1 repairs damaged DNA by hydrolyzing phosphodiester bonds at DNA termini. It mainly expresses in the nucleus of proliferating cells where DNA damage frequently occurs due to cellular division and environmental stress. TDP1 activity is critical in resolving stalled topoisomerase I-DNA complexes created during transcription and replication.
Biological function summary
TDP1 functions to maintain genomic stability by participating in the single-strand break repair (SSBR) mechanism. It is not known to be part of a larger protein complex but interacts with several other proteins to fulfill its role. This protein’s function in DNA repair mechanisms suggests that its activity prevents the accumulation of DNA lesions which could potentially result in genomic instability if left unchecked.
Pathways
TDP1 plays an essential role in the DNA repair pathways. The single-strand DNA break repair pathway is one primary pathway involving TDP1. This pathway is important for maintaining DNA integrity after damaging events such as oxidative stress. TDP1 collaborates with proteins like XRCC1 in these pathways to facilitate efficient DNA repair processes.
Disruptions in TDP1 activity have links with neurodegenerative diseases like spinocerebellar ataxia with axonal neuropathy (SCAN1). Inefficient DNA repair due to TDP1 mutations can lead to accumulated DNA damage contributing to this disorder. Moreover TDP1 might interact with altered PARP1 function in conditions where DNA repair defects underlie the pathophysiology. The study of TDP1 gives insight into mechanisms by which DNA repair deficiencies contribute to diseases.