Abcam, ab141296, Indirubin-3'-monoxime, GSK3beta inhibitor. CDK inhibitor.

Size: 5mg / 25mg
MW 277.28 g/mol, Purity >98%. Potent GSK3β inhibitor (IC 50 = 22 nM). CDK inhibitor (IC 50 values are 0.1 (Cdk5/p35), 0.18 (Cdk1/cyclin B), 0.25 (Cdk2/cyclin E), 0.5 (Cdk2/cyclin A) and 3.3 μM (Cdk4/cyclin D1)). Shows reversible antiproliferative effects via G 2 /M cell cycle arrest. Prevents tau phosphorylation. Shows neuroprotective effects in vivo. .
Key facts
CAS number:160807-49-8,
Purity:>98%,
Molecular weight:277.28 g/mol,
Molecular formula:C16H11N3O2,
Nature:Synthetic,
Biological description:Potent GSK3β inhibitor (IC50 = 22 nM). CDK inhibitor (IC50 values are 0.1 (Cdk5/p35), 0.18 (Cdk1/cyclin B), 0.25 (Cdk2/cyclin E), 0.5 (Cdk2/cyclin A) and 3.3 μM (Cdk4/cyclin D1)). Shows reversible antiproliferative effects via G2/M cell cycle arrest. Prevents tau phosphorylation. Shows neuroprotective effects in vivo.,
Isomeric smiles:O\N=C3/C4CCCCC4N/C3=C1/C2CCCCC2NC1=O,
InChi:InChI=1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,17,21H,(H,18,20)/b15-13-,19-14+,
InChiKey:HBDSHCUSXQATPO-BGBJRWHRSA-N,
IUPAC Name:3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions