Abcam, ab141434, S3I-201, STAT3 inhibitor

Size: 5mg / 25mg
MW 365.4 Da, Purity >97%. Selective STAT3 inhibitor (IC 50 values are 86, 160, 166 and >300 μM for STAT3.STAT3, STAT1.STAT3 STAT1.STAT1 and STAT5.STAT5 DNA binding activity respectively). Suppresses fibronectin, α-SMA, and collagen I expression. Shows apoptotic antiproliferative effects. Shows anti-inflammatory and analgesic effects in vivo. Centrally active.
Key facts
CAS number:501919-59-1,
Purity:>97%,
Molecular weight:365.4 Da,
Molecular formula:C16H15NO7S,
PubChem:252682,
Nature:Synthetic,
Solubility:Soluble in DMSO to 25 mM,
Biochemical name:2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid,
Biological description:Selective STAT3 inhibitor (IC50 values are 86, 160, 166 and >300 μM for STAT3.STAT3, STAT1.STAT3 STAT1.STAT1 and STAT5.STAT5 DNA binding activity respectively). Suppresses fibronectin, α-SMA, and collagen I expression. Shows apoptotic antiproliferative effects. Shows anti-inflammatory and analgesic effects in vivo. Centrally active.,
Canonical smiles:CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O,
InChi:InChI=1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21),
InChiKey:HWNUSGNZBAISFM-UHFFFAOYSA-N,
IUPAC Name:2-hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 1775 Stat3 Inhibitor I, S3I-201. 1775-25 is the same size as the 25 mg size of ab141434.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months