Abcam, ab141450, Rosmarinic acid, Polyphenol

Size: 250mg
MW 360.3 Da, Purity >95%. Polyphenol commonly found in Labitae herbs. Shows anti-oxidative and anti-inflammatory and anti-microbial activities. Also inhibits apoptosis.
Key facts
CAS number:20283-92-5,
Purity:>95%,
Form:SolidSee storage information,
Molecular weight:360.3 Da,
Molecular formula:C18H16O8,
PubChem:5281792,
Nature:Synthetic,
Solubility:Soluble in DMSO and in ethanol,
Biochemical name:Rosmarinic acid,
Biological description:Polyphenol commonly found in Labitae herbs. Shows anti-oxidative and anti-inflammatory and anti-microbial activities. Also inhibits apoptosis.,
Canonical smiles:C1=CC(=C(C=C1CC(C(=O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)O)O,
Isomeric smiles:C1=CC(=C(C=C1C[C@H](C(=O)O)OC(=O)/C=C/C2=CC(=C(C=C2)O)O)O)O,
InChi:InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1,
InChiKey:DOUMFZQKYFQNTF-WUTVXBCWSA-N,
IUPAC Name:(2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxypropanoic acid

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 1843 Rosmarinic Acid. 1843-250 is the same size as the 250 mg size of ab141450.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DNA Polymerase beta often referred to as Pol β is an important enzyme in the cell's DNA repair machinery. It has a molecular mass approximately 39 kDa. This enzyme is a member of the DNA polymerase family but is distinct in its activities. Pol β primarily facilitates base excision repair a critical process for maintaining genomic stability. It is expressed widely in various tissues and plays an important role in repairing small lesions and resolving mismatches in DNA. Fyn a member of the Src family of tyrosine kinases interacts with structures in the cytoplasm and affects cellular signaling. Fyn’s activity is important in the regulation of cell signaling and behavior.
Biological function summary
This enzyme not only contributes to the general maintenance of the genome but also interacts with other components of the DNA repair machinery. Pol β is not part of a large complex but works in tandem with scaffold proteins such as XRCC1 which serve as a platform to recruit various repair factors to DNA lesions. This recruitment and subsequent action allow the cell to swiftly repair DNA preventing potential mutations. Fyn modulates intracellular signaling which has implications on cell growth differentiation and other vital cellular responses.
Pathways
Pol β plays a central role in the base excision repair pathway. This pathway is essential for correcting single-strand breaks and non-bulky lesions caused by oxidative stress alkylation and ionizing radiation. It partners with other proteins such as PARP1 in the early stages of this pathway to initiate repair. Similarly Fyn operates in the T-cell receptor signaling pathway influencing immune responses. It can interact with proteins including Lck which is involved in the cascade of signals transmitted through this pathway.
Defects in Pol β function have been associated with increased susceptibility to cancer. Inefficient or faulty repair of DNA lesions leads to mutagenesis and genome instability factors that drive tumorigenesis. Moreover mutations within its structure link it to certain types of oral cancers. Fyn on the other hand has a connection to neurodegenerative disorders such as Alzheimer's disease where it interacts with tau protein contributing to tau phosphorylation and neurofibrillary tangle formation. Together these interactions underline the significance of Pol β and Fyn in health and disease contexts.