Abcam, ab141469, PYR-41, Ubiquitin-activating enzyme (E1) inhibitor

Size: 5mg / 25mg
MW 371.3 Da, Purity >98%. Ubiquitin-activating enzyme (E1) inhibitor (IC 50 = 5 μM). Inhibits ubiquitination and proteasomal degradation. Additionally increases sumoylation of proteins and induces p53-mediated apoptosis.
Key facts
CAS number:418805-02-4,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:371.3 Da,
Molecular formula:C17H13N3O7,
PubChem:5335621,
Nature:Synthetic,
Solubility:Soluble in DMSO to 50 mM,
Biochemical name:Pyr-41,
Biological description:Ubiquitin-activating enzyme (E1) inhibitor (IC50 = 5 μM). Inhibits ubiquitination and proteasomal degradation. Additionally increases sumoylation of proteins and induces p53-mediated apoptosis.,
Canonical smiles:CCOC(=O)C1=CC=C(C=C1)N2C(=O)C(=CC3=CC=C(O3)[N+](=O)[O-])C(=O)N2,
Isomeric smiles:CCOC(=O)C1=CC=C(C=C1)N2C(=O)/C(=C\C3=CC=C(O3)[N+](=O)[O-])/C(=O)N2,
InChi:InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9-,
InChiKey:ARGIPZKQJGFSGQ-LCYFTJDESA-N,
IUPAC Name:ethyl 4-[(4Z)-4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl]benzoate

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 1925 PYR-41. 1925-25 is the same size as the 25 mg size of ab141469.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months