Abcam, ab142052, Gefitinib, EGFR tyrosine kinase inhibitor

Size: 50mg / 250mg
MW 446.9 Da, Purity >98%. Orally active, potent, selective EGFR (Epidermal growth factor receptor) tyrosine kinase inhibitor (IC 50 = 33 nM). Inhibits EGF-stimulated EGFR autophosphorylation and inhibits tumor growth in vivo . Enhances efficacy of cytotoxic agents. Inhibits growth factor production and angiogenesis. Clinically useful anticancer agent.
Key facts
CAS number:184475-35-2,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:446.9 Da,
Molecular formula:C22H24ClFN4O3,
PubChem:123631,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM,
Biochemical name:Gefitinib,
Biological description:Orally active, potent, selective EGFR (Epidermal growth factor receptor) tyrosine kinase inhibitor (IC50 = 33 nM). Inhibits EGF-stimulated EGFR autophosphorylation and inhibits tumor growth in vivo. Enhances efficacy of cytotoxic agents. Inhibits growth factor production and angiogenesis. Clinically useful anticancer agent.,
Canonical smiles:COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4,
InChi:InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27),
InChiKey:XGALLCVXEZPNRQ-UHFFFAOYSA-N,
IUPAC Name:N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions