Abcam, ab142096, GW 2580, cFMS RTK inhibitor

Size: 5mg / 25mg
MW 366.4 Da, Purity >99%. Selective cFMS (colony stimulating factor 1) RTK inhibitor. Inhibits monocyte growth in vitro (IC 50 = 0.2 μM) and LPS-induced TNF-α production in vivo . Inhibits macrophage infiltration of the CNS. Orally active. Cell-permeable.
Key facts
CAS number:870483-87-7,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:366.4 Da,
Molecular formula:C20H22N4O3,
PubChem:11617559,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM,
Biochemical name:5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine,
Biological description:Selective cFMS (colony stimulating factor 1) RTK inhibitor. Inhibits monocyte growth in vitro (IC50 = 0.2 μM) and LPS-induced TNF-α production in vivo. Inhibits macrophage infiltration of the CNS. Orally active. Cell-permeable.,
Canonical smiles:COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC,
InChi:InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24),
InChiKey:MYQAUKPBNJWPIE-UHFFFAOYSA-N,
IUPAC Name:5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes