Abcam, ab142218, TAPI-1, TNF alpha processing inhibitor

Size: 1mg
MW 499.6 Da, Purity >95%. Stable, selective inhibitor of TNF-α processing (IC 50 = ~100 nM). Inhibits TACE (P< 0.01) and other metalloproteases in vivo . Blocks release of TNF-α (IC 50 = 50-100 μM), APP (IC 50 = 1-8 μM), ACE (IC 50 = 10 μM), IL6R (IC 50 = 5-10 μM), TNFRI (IC 50 = 5-10 μM), TNFRII (IC 50 = 25-50 μM), and ObRa (leptin receptor), but not CSF-1 in vivo . Structural analog of TAPI-0.
Key facts
CAS number:171235-71-5,
Purity:>95%,
Form:SolidSee storage information,
Molecular weight:499.6 Da,
Molecular formula:C26H37N5O5,
PubChem:9827273,
Nature:Synthetic,
Solubility:Soluble in DMSO to 10 mM,
Biochemical name:TNF-alpha Protease Inhibitor-1,
Biological description:Stable, selective inhibitor of TNF-α processing (IC50 = ~100 nM). Inhibits TACE (P< 0.01) and other metalloproteases in vivo. Blocks release of TNF-α (IC50 = 50-100 μM), APP (IC50 = 1-8 μM), ACE (IC50 = 10 μM), IL6R (IC50 = 5-10 μM), TNFRI (IC50 = 5-10 μM), TNFRII (IC50 = 25-50 μM), and ObRa (leptin receptor), but not CSF-1 in vivo. Structural analog of TAPI-0.,
Canonical smiles:CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)NC(C)C(=O)NCCN,
Isomeric smiles:C[C@@H](C(=O)NCCN)NC(=O)[C@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)C(CC(C)C)CC(=O)NO,
InChi:InChI=1S/C26H37N5O5/c1-16(2)12-21(15-23(32)31-36)25(34)30-22(26(35)29-17(3)24(33)28-11-10-27)14-18-8-9-19-6-4-5-7-20(19)13-18/h4-9,13,16-17,21-22,36H,10-12,14-15,27H2,1-3H3,(H,28,33)(H,29,35)(H,30,34)(H,31,32)/t17-,21?,22-/m0/s1,
InChiKey:AWNBSWDIOCXWJW-OWHMDLSXSA-N,
IUPAC Name:N-[(2S)-1-[[(2S)-1-(2-aminoethylamino)-1-oxopropan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 2068 TAPI-1. 2068-1 is the same size as the 1 mg size of ab142218.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions