Abcam, ab142856, Clobetasol propionate, Glucocorticoid

Size: 100mg
MW 467 Da, Purity >98%. Glucocorticoid, induces monooxygenase activity in vivo . Alters the structure of tight junctions in epidermis. Smoothened hedgehog pathway receptor agonist. Anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo .
Key facts
CAS number:25122-46-7,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:467 Da,
Molecular formula:C25H32ClFO5,
PubChem:32798,
Nature:Synthetic,
Biochemical name:Clobetasol propionate,
Biological description:Glucocorticoid, induces monooxygenase activity in vivo. Alters the structure of tight junctions in epidermis. Smoothened hedgehog pathway receptor agonist. Anti-inflammatory, immunosuppressive and antimitotic agent. Active in vivo.,
Canonical smiles:CCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CCl,
Isomeric smiles:CCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CCl,
InChi:InChI=1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1,
InChiKey:CBGUOGMQLZIXBE-XGQKBEPLSA-N,
IUPAC Name:[(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The targets Glucocorticoid Receptor Progesterone Receptor Maxi Potassium channel alpha (SLO) Maxi Potassium channel beta (KCNMB1) Androgen Receptor KCNMB4 KCNMB2 and LRRC26 perform distinct mechanical functions in cells. The Glucocorticoid Receptor also known as NR3C1 acts as a transcription factor and is found in cytoplasm. It is about 97 kDa in weight and expressed in many tissues including kidney brain and liver. The Progesterone Receptor or PGR modulates gene expression and is widely expressed in reproductive tissues. The Maxi Potassium channels also known as BK channels consist of alpha and beta subunits like SLO and KCNMB1 KCNMB2 KCNMB4 which contribute to membrane potential regulation and are primarily located in the nervous system and muscles. LRRC26 associated with BK channels acts as an auxiliary subunit to modulate channel activity.
Biological function summary
These targets play integral roles in various physiological processes. The Glucocorticoid Receptor mediates the effects of stress by regulating genes that control metabolism and immune responses. Maxi Potassium channels formed by combinations of SLO and KCNMB proteins regulate potassium ion flow to maintain cellular excitability and vascular tone. The Androgen Receptor influences male sexual development and bone density by controlling the expression of androgen-responsive genes. Together these targets often participate in complexes that integrate signals across cells modulating tissue-specific responses to hormones and external stimuli.
Pathways
Each target protein fits into key biological signaling cascades that maintain homeostasis. The Glucocorticoid Receptor and Androgen Receptor are parts of the steroid hormone signaling pathways influencing genes involved in metabolism inflammation and cell growth. Maxi Potassium channels including their alpha and beta subunits are involved in the calcium signaling pathway affecting neurotransmission and muscle contraction. These pathways involve multiple proteins and cross-talk with other pathways interacting with proteins like estrogen receptors and kinase enzymes.
These targets have significant implications in human health. The Glucocorticoid Receptor is linked to Cushing's syndrome and chronic stress disorders where dysregulation leads to disturbed cortisol production. Androgen Receptor abnormalities are associated with prostate cancer and androgen insensitivity syndrome reflecting disrupted androgen signaling. Maxi Potassium channels interact with proteins like calcium-activated potassium channel blockers and are implicated in hypertension and epilepsy where ion channel dysfunction alters neuronal excitability and blood pressure regulation.