Abcam, ab14373, Anti-Basal Bodies of Cillia antibody [LhS28]

Size: 50µg
Mouse Monoclonal Human Basal Bodies of Cillia antibody. Suitable for IHC-P, IHC-Fr, IP and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Cell preparation containing Human Basal Bodies of Cillia protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:LhS28,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-Fr, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody recognises the basal bodies of cillia in all cilliated cells.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Basal bodies are structural organelles that serve as the microtubule-organizing centers of cilia and flagella. Also known as basal granules or kinetosomes basal bodies form the base from which the axoneme of the cilia or flagella extends. They possess a cylindrical shape composed of nine triplet microtubules arranged akin to centrioles and typically share a similar molecular mass. These structures are expressed ubiquitously in ciliated cells across various tissues such as the respiratory epithelium and the ventricular ependyma highlighting their ubiquitous presence in multicellular organisms.
Biological function summary
Basal bodies function as critical regulators of cilia formation and maintenance. They play an essential role in positioning and anchoring cilia to the cell surface ensuring proper orientation. Basal bodies are a component of a larger ciliary complex that includes proteins such as dynein arms and the ciliary membrane. These complexes participate in selective protein trafficking facilitating the growth and function of cilia by transporting necessary molecular components.
Pathways
Basal bodies interface with important cellular signaling pathways including the Hedgehog and Wnt pathways. These pathways are important for cell differentiation and developmental processes. Basal bodies interact with proteins such as Gli in the Hedgehog pathway and Dishevelled in the Wnt pathway regulating signal transduction mechanisms critical to maintaining cellular homeostasis.
Basal bodies relate closely to ciliopathic conditions like Primary Ciliary Dyskinesia and Polycystic Kidney Disease. These disorders often arise due to defects in cilia formation and function linked to basal body malfunction. The dysfunction in basal bodies can affect proteins like dynein leading to impaired ciliary motility in disorders such as Primary Ciliary Dyskinesia or defects in cyst formation in Polycystic Kidney Disease.