Abcam, ab143833, LY 2228820, p38 MAPK inhibitor

Size: 5mg / 25mg
MW 612.7 Da, Purity >98%. LY 2228820 is a novel and potent p38 MAPK inhibitor with potent anti-inflammatory activity. It significantly inhibited phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMSCs. LY 2228820 is a potential candidate to improve MM patient outcome both by enhancing the effect of Bortezomib (B675700) and by reducing osteoskeletal events. IC 50 of 7 nM in a cell-free assay.
Key facts
CAS number:862507-23-1,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:612.7 Da,
Molecular formula:C26H37FN6O6S2,
PubChem:11570805,
Nature:Synthetic,
Solubility:Soluble in water to 163.2 mMSoluble in DMSO to 6.52 mMSoluble in Ethanol to 4.89 mM,
Biochemical name:Ralimetinib Mesylate,
Biological description:LY 2228820 is a novel and potent p38 MAPK inhibitor with potent anti-inflammatory activity. It significantly inhibited phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMSCs. LY 2228820 is a potential candidate to improve MM patient outcome both by enhancing the effect of Bortezomib (B675700) and by reducing osteoskeletal events. IC50 of 7 nM in a cell-free assay.,
Canonical smiles:CC(C)(C)CN1C2=C(C=CC(=N2)C3=C(N=C(N3)C(C)(C)C)C4=CC=C(C=C4)F)N=C1N.CS(=O)(=O)O.CS(=O)(=O)O,
InChi:InChI=1S/C24H29FN6.2CH4O3S/c1-23(2,3)13-31-20-17(28-22(31)26)12-11-16(27-20)19-18(14-7-9-15(25)10-8-14)29-21(30-19)24(4,5)6;2*1-5(2,3)4/h7-12H,13H2,1-6H3,(H2,26,28)(H,29,30);2*1H3,(H,2,3,4),
InChiKey:NARMJPIBAXVUIE-UHFFFAOYSA-N,
IUPAC Name:5-[2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)imidazo[4,5-b]pyridin-2-amine;methanesulfonic acid

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B1702 LY2228820. B1702-25 is the same size as the 25 mg size of ab143833.
Protect from air and light.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions