Abcam, ab14429, Anti-ZCWCC1 antibody

Size: 100µg
Rabbit Polyclonal ZCWCC1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human MORC2 aa 600-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MORC2 aa 600-700. The exact immunogen used to generate this antibody is proprietary information.Q9Y6X9,
Specificity:We have data to indicate that this antibody may not cross react with Mouse. However, this has not been conclusively tested and expression levels may vary in certain cell lines/tissues.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified using an epitope specific to ZCWCC1 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.1% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein ZCWCC1 also known as Zinc Finger CW-type Coiled-Coil Domain 1 is a molecular entity with a molecular mass of approximately 85 kDa. ZCWCC1 exists mainly in the nucleus of the cell where it plays a role in the regulation of gene expression. It exhibits a zinc finger motif which allows it to interact with DNA or RNA. Expression of ZCWCC1 is found across various tissue types but it is more prominent in rapidly dividing cells hinting at its involvement in cell cycle regulation.
Biological function summary
ZCWCC1 is implicated in chromatin modification and remodeling affecting how DNA is packed into chromatin. It forms part of a multiprotein complex that facilitates access to specific genetic regions by modifying histones which are proteins around which DNA winds. ZCWCC1 interacting with other proteins in the complex influences transcription and potentially gene silencing. Its function is integral in maintaining the structural configuration of chromatin and ensuring proper gene expression patterns during cellular processes.
Pathways
The activity of ZCWCC1 is integral to the chromatin organization pathway and the gene expression pathway. ZCWCC1 works in conjunction with proteins like histone deacetylases (HDACs) and histone methyltransferases which are vital for modifying histones and regulating gene transcription. These pathways ensure that genetic information is accurately transcribed and translated during various cellular processes including differentiation and proliferation.
ZCWCC1 has potential implications in cancer and neurodegenerative diseases. Aberrant expression or mutation of ZCWCC1 can lead to uncontrolled cell proliferation linking it to oncogenic processes in certain cancers. In neurodegenerative disorders dysregulation of chromatin remodeling where ZCWCC1 is involved is observed alongside factors like tau protein suggesting a complex interplay in neurodegeneration. Understanding ZCWCC1's role in these disease contexts may offer insights into novel therapeutic targets or biomarkers.