Abcam, ab14442, Anti-Natriuretic peptides A antibody [L11-11-D6-B4]

Size: 50µg
Mouse Monoclonal proANP antibody. Suitable for ELISA and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NPPA aa 100 to C-terminus.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:L11-11-D6-B4,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NPPA aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P01160,
Specificity:ab14442 recognizes synthetic Natriuretic peptides A.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Cell culture supernatant, Protein G purified., Storage buffer-pH: 7.4Constituents: 0.79% Tris HCl, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Natriuretic Peptides A also known as ANP ANF or NPPA are important cardiac hormones made by atrial myocytes in the heart. This peptide with a mass of around 28 amino acids plays an important role mechanically in modulating blood pressure and fluid balance. It achieves this by binding to receptors that activate cyclic GMP (cGMP) production leading to vasodilation. ANP expression is mainly found in cardiac muscle cells but also detected in other tissues under certain conditions.
Biological function summary
These peptides contribute to renal sodium excretion commonly known as natriuresis and also promote diuresis which increases urine volume. ANP functions as a singular hormone without forming part of a complex. Beyond its role in cardiovascular and renal systems ANP influences lipid metabolism and adipocyte functions which may have implications for metabolic health.
Pathways
ANP is engaged in the natriuretic peptide signaling pathway which is important for cardiovascular homeostasis. Within this pathway related proteins include B-type Natriuretic Peptide (BNP) and C-type Natriuretic Peptide (CNP) all of which share similar receptor interactions through cGMP. Additionally ANP impacts the renin-angiotensin system (RAS) a significant hormonal system regulating blood pressure and fluid balance by counteracting the actions of angiotensin II.
ANP is notably associated with heart failure where its levels can indicate disease severity and prognosis. Elevated ANP levels have also been linked to hypertension contributing to diagnostic evaluations alongside other biomarkers like BNP. Both heart failure and hypertension involve complex interactions between ANP and proteins such as angiotensin II within their pathophysiological frameworks.