Abcam, ab144422, CAY10585, HIF-1alpha inhibitor

Size: 5mg / 10mg / 25mg
MW 435.5 Da, Purity >97%. HIF-1α inhibitor (IC 50 values are 2.6 and 0.7 μM for Hep3B and AGS cell lines respectively). Suppresses transcription of HIF-1 target genes VEGF and erythropoietin at 10 μM. Attenuates hypoxia-induced ANP secretion. Blunts BMP9-induced osteogenic signaling in MSCs.
Key facts
CAS number:934593-90-5,
Purity:>97%,
Form:SolidSee storage information,
Molecular weight:435.5 Da,
Molecular formula:C26H29NO5,
PubChem:35028748,
Nature:Synthetic,
Solubility:Soluble in DMSO to 10 mM,
Biochemical name:3-[[2-[4-(2-Adamantyl)phenoxy]-1-oxoethyl]amino]-4-hydroxybenzoic acid methyl ester,
Biological description:HIF-1α inhibitor (IC50 values are 2.6 and 0.7 μM for Hep3B and AGS cell lines respectively). Suppresses transcription of HIF-1 target genes VEGF and erythropoietin at 10 μM. Attenuates hypoxia-induced ANP secretion. Blunts BMP9-induced osteogenic signaling in MSCs.,
Canonical smiles:COC(=O)C1=CC(=C(C=C1)O)NC(=O)COC2=CC=C(C=C2)C3C4CC5CC(C4)CC3C5,
InChi:InChI=1S/C26H29NO5/c1-31-26(30)18-4-7-23(28)22(13-18)27-24(29)14-32-21-5-2-17(3-6-21)25-19-9-15-8-16(11-19)12-20(25)10-15/h2-7,13,15-16,19-20,25,28H,8-12,14H2,1H3,(H,27,29),
InChiKey:CSCOJWVRGOZGPK-UHFFFAOYSA-N,
IUPAC Name:methyl 3-[[2-[4-(2-adamantyl)phenoxy]acetyl]amino]-4-hydroxybenzoate

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months