Abcam, ab144518, Sinefungin, methyltransferase inhibitor

Size: 1mg
MW 381.39 Da, Purity >98%. Potent, competitive methyltransferase inhibitor (IC 50 values are < 1 and 2.5 μM for PRMT1 abd SET7/9 respectively). Nucleoside S-adenosylmethionine analog. Inhibits RNA synthesis. Shows antibacterial effects.
Key facts
CAS number:58944-73-3,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:381.39 Da,
Molecular formula:C15H23N7O5,
PubChem:65482,
Nature:Synthetic,
Solubility:Soluble in water,
Biochemical name:Sinefungin,
Biological description:Potent, competitive methyltransferase inhibitor (IC50 values are < 1 and 2.5 μM for PRMT1 abd SET7/9 respectively). Nucleoside S-adenosylmethionine analog. Inhibits RNA synthesis. Shows antibacterial effects.,
Canonical smiles:C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)CC(CCC(C(=O)O)N)N)O)O)N,
Isomeric smiles:C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)C[C@H](CC[C@@H](C(=O)O)N)N)O)O)N,
InChi:InChI=1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/t6-,7-,8+,10+,11+,14+/m0/s1,
InChiKey:LMXOHSDXUQEUSF-YECHIGJVSA-N,
IUPAC Name:(2S,5S)-2,5-diamino-6-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]hexanoic acid

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Interferon gamma (IFN-γ) PRMT1 and EHMT1/GLP are significant proteins with distinct yet interrelated functions. Interferon gamma also known as IFN-g or type II interferon plays a role in immune response regulation. It has a mass of approximately 20 kDa. This cytokine is mainly expressed in activated natural killer cells and T lymphocytes. Protein arginine methyltransferase 1 (PRMT1) is involved in protein methylation with a mass of about 42 kDa and is widely expressed in various tissues. EHMT1 also called GLP (G9a-like protein) primarily functions in histone methylation weighs around 150 kDa and is present in several cell types particularly in brain and embryonic tissues.
Biological function summary
These proteins carry out essential tasks within cellular processes. Interferon gamma facilitates immune surveillance and modulates antigen presentation by inducing class II major histocompatibility complex on antigen-presenting cells. PRMT1 methylates arginine residues influencing signal transduction and transcriptional activation. It forms part of a coactivator complex that regulates gene expression. EHMT1/GLP a histone methyltransferase contributes to chromatin modification affecting gene silencing and genomic imprinting. It often pairs with G9a to form a methylation complex impacting epigenetic regulation.
Pathways
These proteins participate in vital biological networks. Interferon gamma is integral to the JAK-STAT signaling pathway coordinating immune responses and interacting with JAK1 and STAT1 proteins. PRMT1 and EHMT1/GLP are both involved in pathways linked to chromatin remodeling and gene expression regulation. PRMT1 associates with the PI3K/AKT pathway influencing cell growth and survival. EHMT1 collaborates within pathways promoting histone modification functioning closely with proteins like HDACs and SUV39H1.
These proteins associate with various medical conditions. Interferon gamma has links to autoimmune diseases such as rheumatoid arthritis due to its role in immune regulation. It interacts with proteins like TNF-alpha in this context. PRMT1 can relate to cancers including breast cancer through its participation in cell proliferation and signal transduction. In some cancer contexts both PRMT1 and EHMT1/GLP show collaboration in aberrant gene expression leading to tumor progression. Integrating with components like p53 and PI3K they highlight their involvement in oncogenic processes.