Abcam, ab144564, PD123319 di(trifluoroacetate), angiotensin AT2 receptor antagonist

Size: 10mg / 50mg
MW 736.7 Da, Purity >96%. Potent, selective, non-peptide angiotensin AT2 receptor antagonist (IC50 values are 34 and 210 nM for rat adrenal and brain tissue respectively). Reduces angiotensin II-induced oxidative stress. Orally active.
Key facts
CAS number:136676-91-0,
Purity:>96%,
Form:SolidSee storage information,
Molecular weight:736.7 Da,
Molecular formula:C35H34F6N4O7,
PubChem:6604951,
Nature:Synthetic,
Solubility:Soluble in water to 100 mM,
Biochemical name:PD 123319 ditrifluoroacetate,
Biological description:Potent, selective, non-peptide angiotensin AT2 receptor antagonist (IC50 values are 34 and 210 nM for rat adrenal and brain tissue respectively). Reduces angiotensin II-induced oxidative stress. Orally active.,
Canonical smiles:CC1=C(C=CC(=C1)CN2C=NC3=C2CC(N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O,
Isomeric smiles:CC1=C(C=CC(=C1)CN2C=NC3=C2C[C@H](N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O,
InChi:InChI=1S/C31H32N4O3.2C2HF3O2/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24;2*3-2(4,5)1(6)7/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38);2*(H,6,7)/t28-;;/m0../s1,
InChiKey:GPKQIEZLHVGJQH-ZXVJYWQYSA-N,
IUPAC Name:(6S)-1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid;2,2,2-trifluoroacetic acid

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Angiotensin II Type 2 Receptor also known as the AT2 receptor mechanically functions by binding to angiotensin II a peptide hormone that regulates blood pressure. The AT2 receptor has a mass of approximately 41 kDa. It is mainly expressed in fetal tissues as well as in adult tissues like heart kidney adrenal gland and brain. This receptor belongs to the G protein-coupled receptor family and plays a counter-regulatory role compared to the Angiotensin II Type 1 Receptor (AT1 receptor).
Biological function summary
AT2 receptor mediates actions opposite to those of the AT1 receptor by promoting vasodilation natriuresis and inhibition of cell growth. It does not form stable complexes with the AT1 receptor but acts independently. Additionally the AT2 receptor participates in neural differentiation and can induce apoptosis in specific cell types. These activities highlight its regulatory role in cardiovascular and renal systems.
Pathways
The AT2 receptor is an important player in the renin-angiotensin system (RAS) which is critical for maintaining cardiovascular homeostasis. It antagonizes the effects of the AT1 receptor within the RAS pathway counteracting vasoconstriction and cell proliferation. The AT2 receptor also intersects with the bradykinin pathway further influencing vascular tone and growth inhibition. These interactions illustrate the receptor’s comprehensive role in balancing blood pressure and cellular responses.
AT2 receptor involvement has been noted in cardiovascular disease including hypertension and heart failure. It ameliorates conditions induced by excessive AT1 receptor activation by promoting vasodilation and anti-inflammatory effects. Additionally research connects the AT2 receptor to renal disorders such as diabetic nephropathy where it counters profibrotic and hypertensive mechanisms instigated by the AT1 receptor. Therefore understanding its disease-related mechanisms can inform therapeutic strategies for these conditions.