Abcam, ab144823, IMD 0354, IKKbeta inhibitor

Size: 5mg / 10mg / 50mg
MW 383.67 Da, Purity >98%. Potent, selective cell-permeable IKKβ inhibitor (IC 50 = 250 nM). Blocks IκBα phosphorylation and prevents NF-κB p65 nuclear translocation. Reduces IL-1β and MCP-1 production. Shows antiproliferative effects. Shows anti-inflammatory effects in vivo. .
Key facts
CAS number:978-62-1,
Purity:>98%,
Molecular weight:383.67 Da,
Molecular formula:C15H8ClF6NO2,
PubChem:5081913,
Nature:Synthetic,
Solubility:Soluble in ethanol to 7.74 mMSoluble in DMSO to 262.73 mM,
Biochemical name:N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide,
Biological description:Potent, selective cell-permeable IKKβ inhibitor (IC50 = 250 nM). Blocks IκBα phosphorylation and prevents NF-κB p65 nuclear translocation. Reduces IL-1β and MCP-1 production. Shows antiproliferative effects. Shows anti-inflammatory effects in vivo.,
Canonical smiles:C1=CC(=C(C=C1Cl)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)O,
InChi:InChI=1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25),
InChiKey:CHILCFMQWMQVAL-UHFFFAOYSA-N,
IUPAC Name:N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions