Abcam, ab144834, 1-Deoxynojirimycin, alpha-glycosidase inhibitor

Size: 1mg / 5mg
MW 163.17 Da, Purity >98%. Potent α-glycosidase inhibitor (IC 50 = 30 nM). Antihyperglycemic agent. Downregulates SGLT1, Na + /K + -ATP and GLUT2 expression. Decreases MCP-1 and TNF-α levels. Shows antidiabetic, antiviral, antiobesity and anti-inflammatory effects in vivo. Orally active.
Key facts
CAS number:19130-96-2,
Purity:>98%,
Source:Streptomyces sp.,
Molecular weight:163.17 Da,
Molecular formula:C6H13NO4,
PubChem:29435,
Nature:Native,
Solubility:Soluble in water to 100 mM,
Biochemical name:1-Deoxynojirimycin,
Biological description:Potent α-glycosidase inhibitor (IC50 = 30 nM). Antihyperglycemic agent. Downregulates SGLT1, Na+/K+-ATP and GLUT2 expression. Decreases MCP-1 and TNF-α levels. Shows antidiabetic, antiviral, antiobesity and anti-inflammatory effects in vivo. Orally active.,
Canonical smiles:C1C(C(C(C(N1)CO)O)O)O,
Isomeric smiles:C1[C@@H]([C@H]([C@@H]([C@H](N1)CO)O)O)O,
InChi:InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1,
InChiKey:LXBIFEVIBLOUGU-JGWLITMVSA-N,
IUPAC Name:(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GANAB GAA and MGAM are enzymes part of the family known as glycosidases. GANAB also known as glucosidase II alpha subunit has a molecular mass of about 110 kDa and is broadly expressed in the endoplasmic reticulum. GAA or acid alpha-glucosidase weighs around 105 kDa and primarily expresses in lysosomes. MGAM referred to as maltase-glucoamylase shows a molecular mass of approximately 185 kDa concentrating on the small intestine's brush border. These proteins contribute to the breakdown of carbohydrates specifically acting on glycosidic bonds facilitating glucose conversion to provide energy.
Biological function summary
These glycosidase enzymes play essential roles in carbohydrate metabolism. GANAB processing involves the trimming of glucose residues during N-linked glycoprotein maturation. GAA participates in glycogen degradation converting glycogen to glucose in lysosomes. MGAM functioning in the digestive tract helps digest dietary starch into free glucose units. These enzymes operate as part of enzymatic systems ensuring the proper turnover and processing of large carbohydrate molecules critical for cellular and organismal energy management.
Pathways
GANAB GAA and MGAM fit into the glycoside hydrolysis pathway influencing the degradation of complex carbohydrates. GAA's role in glycogenolysis is important for maintaining energy balance in cells linking to the lysosomal degradation pathway alongside the protein LAMP2. MGAM is associated with the digestion pathway impacting nutrient absorption in conjunction with the enzyme sucrase-isomaltase. These pathways underpin the metabolic processes that convert stored and dietary carbohydrates to bioavailable forms of energy.
These enzymes show significant implications for metabolic storage diseases and digestive disorders. GAA is directly related to Pompe disease a lysosomal storage disorder due to deficient glycogen breakdown. In this condition GAA's functionality closely ties to LAMP proteins which support lysosomal integrity. MGAM influences starch digestion-related conditions such as congenital sucrase-isomaltase deficiency where improper starch breakdown affects nutritional absorption. Understanding these enzyme-related pathways opens opportunities for targeted disease therapies and metabolic interventions.