Abcam, ab145638, KN-93, CaM kinase II inhibitor

Size: 250µg
MW 501 Da, Purity >98%. Potent, cell-permeable CaM kinase II inhibitor (IC 50 = 370 nM). Potent voltage gated K + channel blocker (IC 50 = 307 nM, K V 1.5). Analog of water soluble KN-93 (ab120980). Suppresses early afterdepolarization. Induces ROS generation and apoptosis. Shows central effects in vivo. .
Key facts
CAS number:139298-40-1,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:501 Da,
Molecular formula:C26H29ClN2O4S,
PubChem:5312122,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM (with warming),
Biochemical name:Methoxybenzene-sulfonamide,
Biological description:Potent, cell-permeable CaM kinase II inhibitor (IC50 = 370 nM). Potent voltage gated K+ channel blocker (IC50 = 307 nM, KV1.5). Analog of water soluble KN-93 (ab120980). Suppresses early afterdepolarization. Induces ROS generation and apoptosis. Shows central effects in vivo.,
Canonical smiles:CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC,
Isomeric smiles:CN(C/C=C/C1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC,
InChi:InChI=1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+,
InChiKey:LLLQTDSSHZREGW-AATRIKPKSA-N,
IUPAC Name:N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 2524 KN-93. 2524-250 is the same size as the 250 μg size of ab145638.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months