Abcam, ab145974, PRIMA-1MET, p53 activity

Size: 10mg / 25mg
MW 199.25 Da, Purity >98%. Methylated derivative of PRIMA-1 (ab141641). Restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation. Inhibits thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance.
Key facts
CAS number:5291-32-7,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:199.25 Da,
Molecular formula:C10H17NO3,
PubChem:52918385,
Nature:Synthetic,
Solubility:Soluble in water to 100 mMSoluble in DMSO to 100 mM,
Biochemical name:Apr-246,
Biological description:Methylated derivative of PRIMA-1 (ab141641). Restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation. Inhibits thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance.,
Canonical smiles:COCC1(C(=O)C2CCN1CC2)CO,
InChi:InChI=1S/C10H17NO3/c1-14-7-10(6-12)9(13)8-2-4-11(10)5-3-8/h8,12H,2-7H2,1H3,
InChiKey:BGBNULCRKBVAKL-UHFFFAOYSA-N,
IUPAC Name:2-(hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months