Abcam, ab146597, Dorsomorphin (Compound C) (DMSO solution), AMP-kinase inhibitor

Size: 5mg
MW 399.5 Da, Purity >99%. Potent, selective and reversible inhibitor of AMP-kinase (K i = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable. Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821).
Key facts
CAS number:866405-64-3,
Purity:>99%,
Form:LiquidSee storage information,
Molecular weight:399.5 Da,
Molecular formula:C24H25N5O,
PubChem:11524144,
Nature:Synthetic,
Biochemical name:Dorsomorphin,
Biological description:Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable.Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821),
Canonical smiles:C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3,
InChi:InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2,
InChiKey:XHBVYDAKJHETMP-UHFFFAOYSA-N,
IUPAC Name:6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

Product details:
Supplied in DMSO (10mM).
A natural process can cause the product to crystallize out of solution. Should it happen, it is advised to heat the solution to approximately 55°C and let it cool down before use.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes