Abcam, ab14917, Anti-LYVE1 antibody - BSA and Azide free

Size: 100µg
Anti-LYVE1 antibody - BSA and Azide free (ab14917) is a rabbit polyclonal antibody provided in a PBS only buffer for easy conjugation detecting LYVE1 in IHC-P . Suitable for Mouse . - BSA, sodium azide, and glycerol-free for easy conjugation - Over 280 publications - Trusted since 2004
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse,
Applications:ICC, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Mouse Lyve1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q8BHC0

Product details:
Product Specifications
Anti-LYVE1 antibody - BSA and Azide free (ab14917) is a rabbit polyclonal antibody provided in a carrier-free, conjugation ready format.
ab14917 is validated in ICC and IHC-P in mouse samples.
Carrier-free antibodies are compatible with our best-in-class range of Lightning-Link® conjugation kits.
Anti-LYVE1 antibody - BSA and Azide free (ab14917) specifically detects LYVE1 (UniProt ID: Q8BHC0; Molecular weight: 32kDa) and is sold in 100 ug selling sizes.
Quality and Validation
Antibody clone was first used in a scientific publication in 2006 and has been cited over 286 times in peer reviewed journals and is trusted by the scientific community.
Anti-LYVE1 antibody - BSA and Azide free (ab14917) has 34 independent reviews from customers.
Target Information
LYVE-1 (Lymphatic Vessel Endothelial Receptor 1) is primarily expressed on lymphatic endothelial cells and plays a crucial role in hyaluronan (HA) transport and turnover. It is also involved in lymphangiogenesis and immune responses, with altered LYVE-1 expression linked to various diseases, including cancer and inflammatory conditions. For instance, LYVE-1 expression is downregulated in human liver cancer and cirrhosis. Additionally, it is linked to intramuscular hemangioma and complete androgen insensitivity syndrome. Changes in LYVE-1 expression can impact lymphangiogenesis and immune responses, contributing to disease progression.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Protein-A Chromatography (+his tag depleted)., Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein "LYVE1" also known as Lymphatic Vessel Endothelial Hyaluronan Receptor 1 has a molecular mass of about 60 kDa. This protein is located on the surface of lymphatic endothelial cells. Its expression occurs mainly within the lymphatic vessels serving as an important marker for identifying lymphatic endothelium. LYVE1 facilitates the transportation of hyaluronan an important glycosaminoglycan through lymphatic vessels playing a critical role in the maintenance of extracellular matrix and tissue fluid homeostasis.
Biological function summary
LYVE1 plays a role in lymphatic system regulation and immune cell trafficking. It forms part of a network that binds hyaluronan contributing to the regulation of cell migration and adhesion. This protein interacts with molecules like CD44 and other receptors which also participate in hyaluronan binding. LYVE1's function in maintaining the balance of hyaluronan within tissues is central affecting not only the lymphatic system but also immune responses.
Pathways
LYVE1 engages in both the hyaluronan metabolism and lymphangiogenesis pathways. Its interaction with CD44 plays a significant role in the transport and uptake of hyaluronan influencing cellular processes such as proliferation and motility. These interactions link LYVE1 to pathways controlling fluid balance and immune surveillance marking it as essential for maintaining healthy lymphatic and immune function.
LYVE1 shows a connection to lymphatic-related conditions such as lymphedema and cancer metastasis. Alterations or dysregulation of LYVE1 expression can affect lymphatic function potentially leading to the accumulation of interstitial fluid as seen in lymphedema. In cancer increased LYVE1 expression can relate to tumor metastasis where it functions alongside proteins like VEGFR-3 in promoting lymphatic vessel growth and facilitating cancer cell spread.