Abcam, ab150389, Anti-NAB1 antibody [EPR8227(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NAB1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8227(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NAB1 also known as NGFI-A-binding protein 1 is a transcriptional repressor that interacts with zinc finger proteins to regulate gene expression. NAB1 has a molecular mass of approximately 66 kDa. This protein is expressed in various tissues including the nervous system. It plays a role in modulating the activity of target genes by binding to specific DNA sequences in cooperation with EGR transcription factors.
Biological function summary
NAB1 functions as a critical regulator in cellular processes by forming a complex with EGR-1 also known as early growth response protein 1. This interaction allows NAB1 to influence the expression of several genes involved in cell differentiation proliferation and apoptosis. NAB1 ensures proper cellular responses to environmental stimuli by repressing gene transcription that EGR-1 activates.
Pathways
NAB1 frequently associates with the MAPK/ERK signaling pathway and the apoptotic pathway. In the MAPK/ERK pathway it operates alongside proteins like EGR-1 to influence cellular proliferation and differentiation. Meanwhile NAB1's role in the apoptotic pathway is related to its interaction with genes and proteins regulating cell death enabling cells to respond appropriately to stress signals.
NAB1 has been linked to conditions like cancer and neurodegenerative diseases. Aberrant expression or dysfunction of NAB1 along with changes in other proteins such as EGR-1 can lead to uncontrolled cell growth and transformation contributing to tumorigenesis. Additionally misregulation of NAB1 may play a part in neurodegenerative disorders by affecting neuron survival and death though further research is needed to fully understand these connections.