Abcam, ab150602, Anti-Wnt5b antibody

Size: 50µg
Rabbit Polyclonal WNT5B antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Protein Wnt-5b.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Protein Wnt-5b. The exact immunogen used to generate this antibody is proprietary information.Q9H1J7,
Specificity:BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except WNT5A (71%).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Wnt5b also known as wingless-type MMTV integration site family member 5B is a protein that is part of the Wnt family. It has a mass of approximately 42 kilodaltons. Wnt5b is expressed in various tissues notably in marmoset and human prostate tissue. It acts as a signaling molecule involving in cell communication processes such as cell fate determination proliferation and migration.
Biological function summary
Wnt5b is involved in the regulation of embryonic development and is part of a non-canonical Wnt signaling pathway. It does not form a direct signaling complex but interacts with other proteins to execute its function. Wnt5b has a role in the modulation of cell polarity and movement being important for maintaining the structural integrity of tissues and the developmental processes.
Pathways
Wnt5b plays a role in the planar cell polarity pathway and the Wnt/Ca2+ pathway. It connects to proteins like Dishevelled and Calcium/Calmodulin-dependent protein kinase II (CaMKII) acting to regulate intracellular calcium levels and influence cytoskeletal rearrangement. These pathways are critical for several aspects of cellular function including embryogenesis and tissue maintenance.
Wnt5b is associated with the development and progression of certain cancers including prostate cancer. Changes in Wnt5b signaling can disrupt cell-to-cell communication and lead to tumor growth. Additionally links exist between Wnt5b and other proteins such as beta-catenin in the context of cancer. Understanding these connections can offer insights into potential therapeutic strategies aimed at modulating Wnt5b activity to treat disease.