Abcam, ab150876, Anti-FRY antibody

Size: 100µL
Rabbit Polyclonal FRY antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FRY aa 650-750.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FRY aa 650-750. The exact immunogen used to generate this antibody is proprietary information.Q5TBA9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FRY also known as furry homolog or protein fetal andadults-1 is a protein with an approximate mass of 240 kDa. It plays a critical mechanical role in cellular processes by interacting with microtubules which are structures that assist with cell division and shape maintenance. FRY is expressed widely in tissues but shows particularly high levels in the brain liver and lungs indicating its importance in various organ functions. Researchers also notice influence on gene regulation owing to its role in transcriptional activities.
Biological function summary
FRY contributes to diverse cell activities beyond mechanical support. This protein is part of a complex contributing to cell polarity and mitosis essential for proper cell orientation and division. An important function includes its participation in the organization of mitotic spindles structures needed during cell division to evenly separate chromosomes. Given these functions FRY maintains cell structure integrity and supports proper DNA segregation among daughter cells during mitosis.
Pathways
FRY connects to pivotal cellular pathways such as the cell cycle regulation and spindle assembly pathways. It interacts closely with proteins like Aurora kinase B which is vital for correct chromosome alignment and segregation. FRY’s role within these pathways ensures smooth transitions between different cell cycle stages. This integration shows its multifaceted influence in both central and supporting roles concerning cellular dynamics.
Mutations and abnormalities in FRY expression associate with brain-related conditions including glioma and other neurodevelopmental disorders. Research indicates FRY's linkage to cancer development through its interaction with tumor suppressor proteins like p53 which plays a prominent role in cell cycle arrest and apoptosis. These connections suggest FRY's potential as a target for novel disease treatments and better understanding could lead to advances in therapeutic strategies.