Abcam, ab150917, Anti-C5orf45 antibody

Size: 100µL
Rabbit Polyclonal C5orf45 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MRNIP aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MRNIP aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q6NTE8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C5orf45 also known as Chromosome 5 open reading frame 45 is a protein encoded by the C5orf45 gene. This protein has an approximate mass of 27 kDa. It is mainly expressed in the brain tissue and other areas at lower levels indicating a potential specialized function. Structurally C5orf45's exact mechanical function is not fully understood which suggests that more research may be required for the determination of its precise role in cellular mechanisms.
Biological function summary
C5orf45 may contribute to cellular development processes in the brain. It has been suggested that C5orf45 interacts with other proteins to form functional complexes that may facilitate cell communication or growth regulation. These interactions make it valuable for proper cellular function especially in neural networks where timing and precision are important. The protein does not function in isolation but likely co-operates as part of larger protein networks.
Pathways
Researchers suggest that C5orf45 might participate in signal transduction pathways related to neurodevelopment. It may interact with proteins in these pathways to influence how neuron signals travel and affect brain development. While specific interactions in these pathways are yet to be conclusively mapped the involvement of C5orf45 alongside other protein regulators like NRP1 (Neuropilin-1) points towards a role in neuronal signaling dynamics.
C5orf45's function potentially links it to neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. Some studies have shown changes in the expression levels of C5orf45 in individuals with these conditions. The relationship between C5orf45 and proteins like FMR1 (Fragile X Mental Retardation 1) suggests a complex network may influence the emergence and progression of these disorders. This indicates that C5orf45 may play a contributory role in neurological stability and could be a target for therapeutic research.