Abcam, ab150936, Anti-Eros antibody

Size: 100µL
Rabbit Polyclonal Eros antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CYBC1 aa 100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CYBC1 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9BQA9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The biological target known as Eros also referred to as 'peptides’ or 'anti Eros' is a protein associated with various cellular functions. Eros has a molecular mass typically around 30 kDa. It is expressed in multiple tissues prominently in the cells of the immune system. This protein modulates immune responses and cell signaling. The distribution of Eros is essential for effective cellular defense mechanisms.
Biological function summary
The function of Eros extends beyond simple protein interactions. It contributes significantly to reactive oxygen species (ROS) production which is important in phagocytic processes. Eros acts as part of the NADPH oxidase complex a multi-component enzyme system found within phagocytes. The assembly of this complex remains fundamental for generating ROS facilitating microbial killing during immune defenses and inflammation.
Pathways
Eros operates intricately within the immune response modulation and redox regulation pathways. It plays an important role in the oxidative burst pathway where its presence is necessary for proper NADPH oxidase function. This involves interactions with protein components such as gp91phox and p22phox which are part of the membrane-bound cytochrome b558. Eros helps to maintain optimal activity of this complex ensuring effective pathogen destruction.
Eros is linked with chronic granulomatous disease (CGD) and inflammatory response dysregulation. Deficient Eros function can lead to CGD a condition caused by an inability to produce sufficient ROS for microbial destruction. This connection highlights the relationships between Eros and other components of the NADPH oxidase complex including p47phox which also suffers mutations in CGD. Dysfunctional Eros may also contribute to inflammatory disorders potentially influencing disease progression and severity.