Abcam, ab150982, Anti-CCDC72 antibody

Size: 100µL
Rabbit Polyclonal CCDC72 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMA7 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TMA7 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9Y2S6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CCDC72 also known as Coiled-coil Domain Containing 72 is a protein that functions mechanically by contributing to structural and organizational roles within cells. It contains coiled-coil domains which facilitate interactions with other proteins making it an important component of various cellular assemblies. The protein has an approximate mass of 69 kDa. CCDC72 is expressed in multiple tissues but exhibits higher levels in specific regions such as the testis reflecting its involvement in tissue-specific functions.
Biological function summary
CCDC72 participates in processes that include cellular structure maintenance and intracellular signaling. It may be involved as part of larger protein complexes that help regulate the dynamics of the cytoskeleton. These complexes influence the stability and spatial configuration of microtubules and actin filaments in the cell which are key elements for cellular movement division and intracellular transport.
Pathways
CCDC72 significantly contributes to the regulation of the cell cycle and signal transduction pathways. It interacts with key proteins like cyclins and cyclin-dependent kinases which are involved in cell cycle regulation. In signal transduction CCDC72 potentially impacts the Mitogen-Activated Protein Kinase (MAPK) pathway a major pathway that relays growth and differentiation signals within cells. These interactions help modulate the response to extracellular stimuli and intracellular events.
Studies have shown connections between CCDC72 and certain cancers particularly testicular cancer due to its heightened expression in testicular tissue. It may interact with oncogenes like c-Myc within cancerous pathways contributing to tumor growth and proliferation. Additionally there is emerging evidence of a possible link to neurodegenerative disorders although this relationship is not fully understood. Further research into these connections may provide insights into potential therapeutic targets for these conditions.