Abcam, ab151046, Anti-INO80C antibody

Size: 100µL
Rabbit Polyclonal INO80C antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human INO80C.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human INO80C. The exact immunogen used to generate this antibody is proprietary information.Q6PI98

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
INO80C also known as Ino80 complex subunit C is a component of the INO80 chromatin remodeling complex. It plays a critical role in modifying chromatin structure. INO80C with a molecular mass of approximately 81 kDa is widely expressed in human tissues. This protein contributes to the dynamic regulation of chromatin by altering the position and composition of nucleosomes which assists in regulating access to DNA.
Biological function summary
INO80C is involved in maintaining genome stability and is an important player in DNA repair processes. It forms part of the multi-subunit INO80 complex a member of the ATP-dependent chromatin-remodeling family. This complex facilitates the repair of DNA double-strand breaks by promoting homologous recombination a precise DNA repair mechanism. INO80C's role in the complex also supports DNA replication and transcription regulation indicating its importance in cell cycle progression.
Pathways
INO80C is involved in the DNA damage response and repair pathway as well as the transcriptional regulation pathway. Within these pathways INO80C interacts with other proteins such as RAD51 and BRCA1 to assist in the repair of double-strand breaks. It also influences the transcriptional activities by affecting RNA polymerase II-mediated transcription initiation. The interactions with these proteins help integrate INO80C's function into broader cellular responses to DNA damage and gene expression.
INO80C's function connects to cancer and aging-related disorders. Its role in DNA repair and genome stability suggests that abnormalities in INO80C could contribute to genomic instability and tumorigenesis. Furthermore INO80C links to BRCA1 a protein associated with breast and ovarian cancer susceptibility. Dysregulation of INO80C and related pathways might also contribute to premature aging by affecting cellular repair processes.