Abcam, ab151109, Anti-C10orf99 antibody

Size: 100µL
Rabbit Polyclonal C10orf99 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GPR15LG.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human GPR15LG.Q6UWK7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C10orf99 also recognized as Apal is a small peptide with a molecular weight of approximately 10 kDa. It exhibits expression in several tissues with high levels in the skin and certain epithelial regions. This protein plays a role in innate immunity where it acts as an antimicrobial peptide. Researchers have identified its presence as particularly relevant in the context of skin infections and inflammation suggesting its potential importance in barrier function.
Biological function summary
The action of C10orf99 involves modulating the immune response by influencing the activation of immune cells. It does not form part of a complex but interacts directly with cell surface receptors to modify cellular responses. This modulation is vital for maintaining immune homeostasis and combating pathogens as well as managing inflammation in tissue-specific contexts.
Pathways
C10orf99 engages in immune-related pathways involving innate immunity and epidermal defense. It interacts with proteins such as the interleukin family contributing to the signaling cascades that govern inflammation and immune cell recruitment. The protein's role within the Toll-like receptor (TLR) pathway highlights its importance in recognizing pathogen-associated molecular patterns aiding in initiating appropriate immune responses.
C10orf99 links to conditions like psoriasis and atopic dermatitis disorders often characterized by dysregulated immune activity and inflammation. In these contexts proteins such as IL-17 have been noted for their roles with C10orf99 potentially influencing or mediating their effects. Its antimicrobial properties and role in modulating inflammation highlight its potential as a therapeutic target in managing these skin-related disorders.