Abcam, ab151251, Anti-hnRNP R antibody

Size: 100µL
Rabbit Polyclonal hnRNP R antibody. Suitable for ICC/IF, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HNRNPR aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HNRNPR aa 1-200. The exact immunogen used to generate this antibody is proprietary information.O43390

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Heterogeneous nuclear ribonucleoprotein R commonly known as hnRNP R is a multifunctional protein involved in mRNA processing. It is approximately 72 kDa in size and found mostly in the nucleus. hnRNP R exhibits a strong expression in neural tissues and various other cell types. As a member of the hnRNP family it plays an important role in RNA-binding activities and influences the splicing process export and stability of mRNA.
Biological function summary
HnRNP R contributes to several cellular tasks related to gene expression regulation. This protein interacts with other hnRNPs to form core components of ribonucleoprotein complexes. It participates in modulating RNA transport from the nucleus to the cytoplasm and facilitates mRNA translation. Additionally hnRNP R associates with other proteins and RNA molecules strengthening the cellular response to environmental cues.
Pathways
HnRNP R acts decisively in several gene expression and RNA processing pathways. It is involved in the mRNA splicing pathway where it interacts with splicing machinery to process precursor mRNAs into mature mRNAs. hnRNP R also influences the Wnt signaling pathway by regulating the stability and localization of mRNAs involved in this pathway. Moreover it interacts with proteins like hnRNP A1 which further aids its functional capabilities in these pathways.
HnRNP R associates with neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Its interaction with other hnRNPs like TDP-43 suggests a link to the RNA-binding protein misregulation observed in these disorders. Research shows that abnormalities in hnRNP R function can lead to widespread disruption of mRNA processing which contributes to the pathogenesis of neurodegenerative diseases.