Abcam, ab151456, Anti-LAE antibody

Size: 100µL
Rabbit Polyclonal LAE antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ACSM1 aa 1-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ACSM1 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.Q08AH1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target LAE also known by some researchers as HXLM is a notable protein with a mass typically around 58 kDa. It is located throughout various tissues but shows high expression levels in the liver and kidneys. Specifically LAE is recognized for its binding affinity and interaction with several cellular substrates playing a direct role in various cellular activities. The protein's structural characteristics allow it to engage in essential biochemical reactions within the cell.
Biological function summary
LAE contributes significantly to cellular metabolism and regulation processes. It is part of a multimeric complex where it functions collaboratively with other proteins to maintain cellular balance. LAE is involved in energy production and molecule conversion making it critical in supporting cells under stress conditions. Its complex formation aids in transporting molecules across the cell membrane linking it to essential cellular operations.
Pathways
LAE interacts predominantly with the glycolysis and gluconeogenesis pathways. In these pathways it associates with the enzyme hexokinase assisting in glucose breakdown and synthesis. This protein's involvement ensures efficient energy circulation and utilization within the cell. Additionally LAE connects with phosphofructokinase in modulating pathway activities highlighting its influence on broader metabolic functions.
LAE has strong connections to diabetes and renal dysfunction. Dysregulation of this protein can result in abnormal glucose metabolism a hallmark of diabetic conditions. When linked to disorders LAE's relationship with insulin-like growth factor binding protein plays a part in managing glucose levels and kidney health. Such associations deepen the understanding of LAE's potential as a therapeutic target in treating metabolic and renal diseases.