Abcam, ab151691, Anti-OSBPL9 antibody [EPR9333]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal OSBPL9 antibody. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9333,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OSBPL9 also referred to as oxysterol-binding protein-like 9 is a member of the oxysterol-binding protein (OSBP)-related protein family. This protein family involves intracellular lipid transport. OSBPL9 has a molecular weight of approximately 89 kDa. It is expressed in various tissues with high levels in brain pancreas and intestine. The protein possesses a pleckstrin homology domain and a conserved OSBP-related domain which play roles in binding to lipids and facilitating their transport within cells.
Biological function summary
OSBPL9 participates in lipid metabolism and cellular lipid homeostasis. It binds to phosphoinositides and sterols regulating lipid distribution and signaling. Studies indicate that OSBPL9 forms part of a complex involved in the transfer of lipids at the membrane contact sites between organelles such as the endoplasmic reticulum and the Golgi apparatus. These interactions highlight its integral role in maintaining lipid equilibrium across cellular compartments.
Pathways
A deeper understanding of OSBPL9 shows its involvement in signaling pathways alongside other lipid-binding proteins. It plays a significant role within the sterol regulatory element-binding protein (SREBP) signaling pathway and potentially the PI3K-Akt signaling pathway. These pathways are essential in lipid synthesis and cellular growth. OSBPL9 shares functional interactions with proteins like OSBP and other OSBP-related proteins emphasizing its collaborative involvement in these pathways.
OSBPL9 association with dyslipidemia and metabolic disorders has been observed due to its influence on lipid homeostasis. Alterations in OSBPL9 function may contribute to abnormal lipid levels impacting conditions like atherosclerosis. The protein's connection to metabolic pathways suggests a linkage with proteins such as OSBPL10 further indicating its potential involvement in the pathogenesis of these metabolic disorders. Researchers continue to study OSBPL9 to better understand its role in these diseases.