Abcam, ab151723, Anti-UBXN1 antibody [EPR9136]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal UBXN1 antibody. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9136,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UBXN1 also known as UBX domain-containing protein 1 has a major role in regulating protein degradation through the ubiquitin-proteasome system. This protein weighs approximately 38 kDa. UBXN1 is expressed ubiquitously with higher levels reported in tissues such as kidney liver and brain. It interacts with the p97/VCP ATPase modulating its activity in protein degradation. By binding to ubiquitin chains UBXN1 influences the fate of many substrates targeted for degradation.
Biological function summary
UBXN1 serves as a regulator in processes such as protein homeostasis and stress response. It functions as part of a large protein complex that includes elements like p97/VCP which are central to maintaining cellular protein balance. UBXN1 modulates processes involving endoplasmic reticulum-associated degradation (ERAD). It therefore plays a role in the quality control of misfolded proteins preventing their accumulation and potential toxicity in cells.
Pathways
UBXN1 is closely associated with the ubiquitin-proteasome pathway a critical system for protein turnover. It acts along with proteins such as p97/VCP and works in tandem with ubiquitin enzymes to regulate protein substrates. Additionally UBXN1 has a role in autophagy-related pathways where it assists in removing damaged proteins and organelles cooperating with signalling proteins like LC3 which are essential for autophagic vesicle formation.
UBXN1 has connections with neurodegenerative diseases and cancer. Its involvement in protein homeostasis and degradation pathways links UBXN1 to neurodegenerative conditions where mismanagement of protein quality control is a hallmark. The dysregulation of UBXN1 alongside proteins p97/VCP has been associated with inclusion body myopathy and other degenerative diseases. Moreover alterations in UBXN1 expression or function relate to cancer progression as its imbalance can lead to uncontrolled cell growth through disrupted protein degradation mechanisms.