Abcam, ab151736, Anti-AIBZIP antibody [EPR7382]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal AIBZIP antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7382,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AIBZIP also known as Activating Immune Response Protein BZIP is a transcription factor involved in regulating gene expression. This protein with a molecular mass of approximately 45 kDa plays an important role in cellular functioning. Researchers have observed AIBZIP expression mainly in the immune cells including B and T lymphocytes. It regulates genes involved in immune responses by binding to DNA at specific sites assisting in the control of gene transcription.
Biological function summary
AIBZIP is a regulator of immune cell communication and response. AIBZIP forms a complex with other bZIP family proteins enabling it to influence a wide range of cellular processes. AIBZIP modulates expression of cytokines and other immunologically relevant genes. Proper function of AIBZIP ensures cells can effectively respond to pathogens and maintain immune homeostasis.
Pathways
AIBZIP acts in the NF-kB signaling pathway and JAK-STAT pathway both important for immune response and inflammation regulation. It interacts with proteins like RelA in the NF-kB pathway which modulates inflammatory responses and STAT3 in the JAK-STAT pathway that affects cellular growth and differentiation. Through these pathways AIBZIP influences many immune system functions and contributes to the regulation of immune cell activity.
AIBZIP impacts conditions like autoimmune disorders and certain cancers. Dysregulation of AIBZIP can lead to improper immune responses contributing to autoimmune diseases such as lupus. It also links to cancerous processes by affecting the immune system’s ability to fight tumor cells interacting with proteins like p53 that are important for cell cycle regulation. Understanding these interactions can help in developing targeted therapies for such diseases.