Abcam, ab151964, Anti-FBXO16 antibody

Size: 100µL
Rabbit Polyclonal FBXO16 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FBXO16 aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FBXO16 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8IX29

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FBXO16 also known as F-box only protein 16 is a component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. It plays a role in targeting proteins for ubiquitination and subsequent proteasomal degradation. The molecular mass of FBXO16 is approximately 45 kDa. This protein is expressed in various tissues with significant levels observed in the brain and reproductive organs. Its expression pattern suggests an involvement in diverse cellular processes depending on tissue type.
Biological function summary
F-box proteins like FBXO16 are important in regulating the stability of specific proteins. FBXO16 is part of the SCF complex which functions as a molecular machinery to control protein turnover by attaching ubiquitin to target proteins. This process marks them for degradation maintaining cellular protein homeostasis. Proper function of such networks is essential for regulating cell cycle growth and response to environmental stimuli among other cellular processes.
Pathways
FBXO16 plays a role in ubiquitin-proteasome pathways. It interacts within pathways that involve protein degradation impacting cellular processes like cell cycle regulation and apoptosis. Additionally FBXO16 interacts with proteins involved in signaling pathways such as those modulating p53 a critical protein for DNA repair and apoptosis. These interactions highlight FBXO16’s impact on maintaining cellular health and responding to cellular stress.
FBXO16 links to cancers due to its role in protein degradation pathways that control cell proliferation. Alterations in FBXO16 expression or function can disrupt normal regulatory processes leading to tumor development and progression. Furthermore there is evidence suggesting FBXO16 interacts with proteins such as p53 and beta-catenin which are also implicated in cancer pathways. This connection indicates potential FBXO16 involvement in tumorigenesis and highlights its importance as a target for therapeutic intervention.