Abcam, ab151967, Anti-DGKG antibody

Size: 100µL
Rabbit Polyclonal DGKG antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DGKG aa 450-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DGKG aa 450-700. The exact immunogen used to generate this antibody is proprietary information.P49619

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DGKG also known as diacylglycerol kinase gamma is an important enzyme that phosphorylates diacylglycerol (DAG) to produce phosphatidic acid (PA). This enzyme possesses a molecular mass of approximately 90 kDa. DGKG is expressed in many tissues with particularly high levels in brain and muscle. Its expression in these areas indicates a significant role in neuronal signaling and muscle function.
Biological function summary
DGKG influences various cellular processes by transforming diacylglycerol into phosphatidic acid. This enzymatic activity regulates the levels of DAG a critical second messenger involved in signal transduction. DGKG does not solely function on its own but is part of larger signaling complexes that mediate signal cascades. Through this involvement DGKG impacts cell growth differentiation and metabolism.
Pathways
DGKG plays a significant role in the phosphatidylinositol signaling pathway. This pathway is essential for transmitting extracellular signals to intracellular responses primarily involving protein kinase C (PKC). DGKG also interacts with proteins such as RAS and RAF kinases indicating its participation in the MAPK/ERK pathway. These interactions highlight its contribution to transmitting signals that regulate cellular proliferation and differentiation.
DGKG shows associations with cancer and neurological disorders. The altered expression or function of DGKG may contribute to oncogenesis by affecting cell signaling pathways that control cell growth. Additionally its role in neuronal signaling links it to neurological conditions possibly through interactions with proteins such as PKC. DGKG's dysregulation in these contexts suggests its potential as a therapeutic target in managing these diseases.