Abcam, ab152676, Recombinant Human beta Sarcoglycan protein

Size: 10µg
Recombinant Human beta Sarcoglycan protein is a Human Full Length protein, in the 1 to 318 aa range, expressed in Wheat germ and suitable for western blot, SDS-PAGE and ELISA. The predicted molecular weight of ab152676 protein is 60.7 kDa. - Save time and ensure accurate results - use our Human beta Sarcoglycan (SGCB) as a control
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:SDS-PAGE, ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q16585,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Product details:
Ensure the validity of your result using our recombinant human beta Sarcoglycan (SGCB) protein ab152676 as a positive control in SDS-PAGE and western blot.
Analyze your Beta-SG ELISA data using the ab152676 protein to generate and plot a standard curve.
Check out our protein gel staining guide for SDS-PAGE
Check out our western blot protocol for more information
Check out our ELISA protocol for more information

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Beta Sarcoglycan is a glycoprotein that has different names including 35DAG or A3b. It plays an important role in muscle cells by integrating into the sarcoglycan complex. This protein has an approximate mass of 43 kDa. It is mainly expressed in skeletal and cardiac muscle tissues. Beta Sarcoglycan provides structural support to the muscle cell membrane by linking inside the dystrophin-associated glycoprotein complex (DGC).
Biological function summary
Beta Sarcoglycan acts to maintain the stability of the muscle cell's sarcolemma. It forms part of the sarcoglycan complex which is one component of a larger dystrophin-glycoprotein complex. This complex protects muscle fibers from the stress of contraction. By ensuring the integrity of the muscle membrane Beta Sarcoglycan contributes to muscle fiber repair and regeneration reducing the risk of damage from repetitive use.
Pathways
Beta Sarcoglycan belongs to the dystrophin-associated glycoprotein complex playing a role in the linkage between the cytoskeleton and extracellular matrix. This involvement occurs primarily in the DGC signaling pathway. The interaction with dystrophin and other sarcoglycans ensures effective signal transduction and mechanical stability during muscle contraction. It relates to proteins including dystrophin itself and other sarcoglycans like alpha and gamma that cooperate in the same pathway.
Beta Sarcoglycan connects closely to limb-girdle muscular dystrophy (LGMD). Mutations in the gene encoding this protein lead to muscle weakness and degeneration characteristic of LGMD. It has a direct relationship with other sarcoglycans like gamma and alpha as defects in these proteins can cause similar dystrophic conditions. The impaired function of Beta Sarcoglycan results in the breakdown of muscle membrane integrity contributing to the progression of the disease.